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Single Euploid Embryo Transfer Outcomes after Uterine Septum Resection

Study Objective: To study pregnancy outcomes after single euploid embryo transfer (SEET) in patients who underwent prior uterine septum resection to those with uteri of normal contour, without M€ullerian anomalies or uterine abnormalities including polyps or fibroids, and without a history of prior uterine surgeries.

Design: Retrospective cohort study.

Setting: Single academic affiliated center.

Patients: 60 cycles of patients with prior hysteroscopic uterine septum resection who underwent an autologous SEET
between 2012 and 2020 were used as the investigational cohort. A 3:1 ratio propensity score matched control cohort of 180 single euploid embryo transfer cycles from patients without a history of uterine septa were used as the control group.

Interventions: No interventions administered.

Measurements and Main Results: Pregnancy, clinical pregnancy loss, ongoing clinical pregnancy, and live birth rates in patients with a history of uterine septum resection compared with matched patients without M€ullerian anomalies or uterine surgeries.
Patients with a prior uterine septum had significantly lower rates of chemical pregnancy (58.33% vs 77.2%, p = .004), implantation (41.67% vs 65.6%, p = .001), and live birth (33.33% vs 57.8%, p = .001) per transfer. No statistical difference in clinical pregnancy loss rates was found when comparing septum patients with controls (8.33% vs 7.8%, p = .89).

Conclusion: Patients with a history of hysteroscopic resection who undergo in vitro fertilization are more susceptible to suboptimal clinical outcomes compared with patients with normal uteri. Early pregnancy loss rates in patients with a uterine septum are higher than in those without; however, after resection, the rates are comparable. Patients born with septate uteri require assessment of surgical intervention prior to SEET, and to optimize their reproductive outcomes. Journal of Minimally Invasive Gynecology (2024) 00, 1−6. © 2024 AAGL. All rights reserved.

Correlation of self‑reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles

Purpose To determine whether the embryonic euploidy rate and live birth outcomes following single, euploid embryo
transfer (SEET) difer among women of self-reported racial and ethnic backgrounds.

Methods This retrospective cohort study included all infertile patients of diferent self-reported racial backgrounds who underwent In vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) and an autologous single euploid embryo transfer (SEET) from December 2015 to December 2019 at a single private and academic assisted reproduction technology center. Primary outcome measures included ploidy rates among diferent racial groups. Secondary outcomes included clinical pregnancy, clinical pregnancy loss, and live birth rates.

Results Five thousand fve hundred sixty-two patients who underwent an IVF cycle with ICSI-PGT-A were included. A
total of 24,491 blastocysts were analyzed. White participants had on average more euploid embryos and higher euploidy
rates when compared to their counterparts (p≤0.0001). However, after controlling for confounding factors, there was no
association between race and the odds of having a higher euploidy rate (aOR 1.31; 95% CI 0.63–2.17, p=0.42). A total of
4949 patients underwent SEET. Pregnancy outcomes did not difer among patients of varying self-reported races.

Conclusions Euploidy rates and pregnancy outcomes were comparable among patients of diferent racial backgrounds who underwent a SEET.

Recent clomiphene citrate exposure does not impact subsequent clinical outcomes in single euploid frozen embryo transfer cycles

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The cumulative dose of gonadotropins used for controlled ovarian stimulation does not influence the odds of embryonic aneuploidy in patients with normal ovarian response

Lucky Sekhon, MD, Kathryn Shaia, MD, Anthony Santistevan MS, Karen Hunter Cohn PhD, Joseph A. Lee, …

Reproductive outcome is optimized by genomic embryo screening, vitrification and subsequent transfer into a prepared synchronous endometrium

Jorge Rodriguez-Purata, MD; Joseph Lee, BA; Michael Whitehouse, BA; Marlena Duke, MS; Lawrence …

Clinically recognizable error rate after the transfer of comprehensive chromosomal screened euploid embryos is low

Werner MD, Leondires MP, Schoolcraft WB, Miller BT, Copperman AB, Robins ED, Arredondo F, Hickman …

Replacing liquid fyrite with digital to improve in vitro fertilization laboratory quality control procedures

Casey A. McDonald, Zachary A. Haimowitz, Andrea DeVenuta, Charity Reeves, Alan B. Copperman, Jason …

Monozygotic pregnancies conceived by in vitro fertilization - understanding their prognosis

Gerardo Vela, M.D., Martha Luna, M.D., Jason Barritt, Ph.D., Benjamin Sandler, M.D., Alan B. …

Commercially available enhanced in vitro maturation medium does not improve maturation of germinal vesicle and metaphase I oocytes in standard in vitro fertilization cases

Moschini RM, Chuang L, Poleshchuk F, Slifkin RE, Copperman AB, Barritt J. Fertil Steril. 2011 Jun …