Published Manuscripts
Tag: Dr. Tanmoy Mukherjee
Effect of various contraceptives on oocyte yield and maturation in patients undergoing planned oocyte cryopreservation: a retrospective cohort study
Research question: Do the various forms of hormonal and non-hormonal contraceptives have any association with ovarian stimulation outcomes, such as oocyte yield and maturation, in patients undergoing planned oocyte cryopreservation (POC)?
Design: This retrospective cohort study included all patients who underwent POC cycles between 2011 and 2023. The use of types of contraception before a POC cycle was recorded. The study evaluated the median number of cumulusoocyte complexes obtained after vaginal oocyte retrieval and the proportion of metaphase II oocytes that underwent vitrification among all the cohorts.
Results: A total of 4059 oocyte freezing cycles were included in the analysis. Eight types of contraceptive method were recognized in patients undergoing ovarian stimulation: intrauterine device (IUD), copper (n = 84); IUD, levonorgestrel low dose (<52 mg) (n = 37); IUD, levonorgestrel (n = 192); subdermal etonogestrel implant (n = 14); injectable medroxyprogesterone acetate (n = 11); etonogestrel vaginal ring (n = 142); combined oral contraceptive pills (n = 2349); and norelgestromin transdermal patch (n = 10). The control group included patients not using contraceptives or using barrier or calendar methods (n = 1220). Among all the cohorts the median number of cumulusoocyte complexes retrieved during oocyte retrieval was comparable (P = 0.054), and a significant difference in oocyte maturity rate with median number of vitrified oocytes was found (P = 0.03, P < 0.001, respectively). After adjusting for confounders a multivariate analysis found no association between the type of contraceptive and proportion of metaphase II oocytes available for cryopreservation.
Conclusions: Among the various forms of contraception, none was shown to have an adverse association with oocyte yield or maturation rate in patients undergoing POC
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Recent clomiphene citrate exposure does not impact subsequent clinical outcomes in single euploid frozen embryo transfer cycles
Carlos Hernandez-Nieto,, Joseph Lee, Tamar Alkon-Meadows, Luz Soto-Cossio, Benjamin Sandler, Tanmoy …
Read MoreAssisted Reproductive Technology Treatment Outcomes in Women With Liver Disease
Lee JD, Gounko D, Lee JA, Mukherjee T, Kushner T. Am J Gastroenterol. 2023 Dec 1;118(12):2184-2190. …
Read MoreParental chromosomal heteromorphisms are not associated with an increased risk of embryo aneuploidy
Hernandez-Nieto, C., Gayete-Lafuente, S., Alkon-Meadows, T., Lee, J., Luna-Rojas, M., Mukherjee, …
Read MoreEndometrial preparation before the transfer of single, vitrified-warmed, euploid blastocysts: does the duration of estradiol treatment influence clinical outcome?
Sekhon L, Feuerstein J, Pan S, Overbey J, Lee JA, Briton-Jones C, Flisser E, Stein DE, Mukherjee T, …
Read MoreReproductive outcome is optimized when an embryo transfer is performed 1 to 3 months after cervical dilation
Jorge Rodriguez-Purata, MD; Robert Pacheco, BA; Lucky Sekhon, MD; Joseph A. Lee, BA; Lawrence …
Read MoreReproductive outcome is optimized by genomic embryo screening, vitrification and subsequent transfer into a prepared synchronous endometrium
Jorge Rodriguez-Purata, MD; Joseph Lee, BA; Michael Whitehouse, BA; Marlena Duke, MS; Lawrence …
Read MoreMaximum basal FSH predicts reproductive outcome better than cycle-specific basal FSH levels: waiting for a “better” month conveys limited retrieval benefits
Gingold JA, Lee JA, Whitehouse MC, Rodriguez-Purata J, Sandler B, Grunfeld L, Mukherjee T, …
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